Genetic Obesity in Children: Overview of Possible Diagnoses with a Focus on SH2B1 Deletion.

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This paper highlights that children with a 16p11.2 deletion involving the SH2B1 gene often develop severe, early‑onset obesity with insulin resistance and related health complications, showing families the importance of early genetic testing and regular screening (for diabetes, liver health, and cholesterol) so care teams can provide proactive, targeted medical support rather than delay diagnosis or rely only on general weight‑management strategies.