Does rare matter? Copy number variants at 16p11.2 and the risk of psychosis: a systematic review of literature and meta-analysis.

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This review and meta-analysis found that individuals with a proximal 16p11.2 duplication have approximately 14 times higher risk of developing psychosis and 16 times higher risk of schizophrenia, which is important information for families monitoring mental health in their loved ones with this variant.