The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity.

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This study found that children and adults with 16p11.2 proximal deletions or duplications show changes in brain structure in areas related to reward, language, and social skills—and these brain changes overlap with those seen in autism and schizophrenia, helping explain why 16p11.2 variants increase the risk for these conditions.