16p11.2 deletion syndrome mice perseverate with active coping response to acute stress – rescue by blocking 5-HT2A receptors.

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This mouse study found that animals modeling the 16p11.2 deletion show repetitive stress responses and altered serotonin signaling, and that blocking a specific serotonin receptor (5-HT2A) with a drug normalized their behavior, suggesting a potential therapeutic target for repetitive behaviors in individuals with the deletion.