Quantifying the Effects of 16p11.2 Copy Number Variants on Brain Structure: A Multisite Genetic-First Study.

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This large brain imaging study found that having a 16p11.2 deletion or duplication causes measurable, opposite ('mirror') effects on brain structure in specific regions like the insula, temporal gyri, caudate, and hippocampus, helping families understand how the genetic change physically affects the brain even when other factors like age or sex vary.