CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1.

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This large genetic study looked at copy number variants (extra or missing pieces of DNA) in people with schizophrenia and found that deletions near the 16p12.1 region (a neighbor to 16p11.2) may increase risk, suggesting that chromosomal changes in the broader 16p region can influence brain development and psychiatric conditions—which may be relevant context for 16p11.2 families thinking about long-term mental health outcomes.