Kctd13 deletion reduces synaptic transmission via increased RhoA.

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Researchers studying the KCTD13 gene (found in the 16p11.2 proximal region) found that deleting it in mice and zebrafish reduces communication between brain cells by raising levels of a protein called RhoA, suggesting that RhoA may be a potential treatment target for families affected by 16p11.2 proximal deletions.