Speech delays and behavioral problems are the predominant features in individuals with developmental delays and 16p11.2 microdeletions and microduplications.

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This large study of 77 individuals with 16p11.2 deletions or duplications found that speech delays and behavioral problems were the most common features, and while some individuals showed signs of autism, many did not—suggesting that additional factors beyond the genetic change itself may be needed to develop autism spectrum disorder.