Histone deacetylase inhibition restores behavioral and synaptic function in a mouse model of 16p11.2 deletion.

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Researchers discovered that a short treatment with epigenetic drugs (HDAC inhibitors) lasting only 3 days significantly improved social behavior and thinking skills in mice with 16p11.2 deletion for up to 3-4 weeks, suggesting this type of medication may be a promising treatment avenue worth exploring for people with 16p11.2 deletion.