Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.

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Researchers studying mice with the 16p11.2 duplication discovered that correcting the copy number of a single gene called PRRT2 was able to reverse seizure susceptibility and social behavior problems, suggesting that targeting this one gene hub may help address multiple symptoms seen in children with this duplication.