Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility.

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This study found that certain autism-linked genes are important for the development of gut nerve cells, and when these genes are disrupted, it can cause stomach and digestive problems—suggesting that the gastrointestinal issues commonly experienced by autistic individuals (including those with 16p11.2 variants) may stem from how gut nerves develop before birth, and that serotonin-targeting medications might offer relief.