The INO80E at 16p11.2 locus increases risk of schizophrenia in humans and induces schizophrenia-like phenotypes in mice.

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This study identifies the INO80E gene within the proximal 16p11.2 region as a risk factor for schizophrenia, showing that increased expression of this gene in the brain's prefrontal cortex leads to schizophrenia-like behaviors in mice, which may help families understand why duplications in this region are associated with psychiatric conditions.