Mice with 16p11.2 Deletion and Duplication Show Alterations in Biological Processes Associated with White Matter.

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This mouse study suggests that both 16p11.2 deletions and duplications change how white matter—the brain’s “communication wiring”—develops and is maintained, but in different ways, helping families understand that learning and thinking differences in 16p11.2 have a biological basis and supporting future research aimed at treatments that target brain connectivity (though this work is still early and not yet clinical).