16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability.

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This mouse study found that the 16p11.2 deletion disrupts brain communication between the frontal and temporal regions, reduces calming brain chemicals (GABA), and—interestingly—enhances attention ability, mirroring similar patterns seen in autistic individuals, which may help explain some behavioral traits seen in children with this deletion.