16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development.

For: All,

Researchers created stem cell lines from 13 individuals with 16p11.2 deletions or duplications and grew them into early brain cells, discovering gene activity changes that may help explain brain development differences—offering a valuable research tool that other scientists can use to better understand the causes of 16p11.2-related conditions.