16p11 Duplication Disrupts Hippocampal-Orbitofrontal-Amygdala Connectivity, Revealing a Neural Circuit Endophenotype for Schizophrenia.

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This mouse study found that having a 16p11.2 duplication disrupts brain connections between the hippocampus, orbitofrontal cortex, and amygdala, leading to problems with working memory and social behavior that closely mirror what is seen in people with schizophrenia, helping researchers better understand why this duplication raises schizophrenia risk.