A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders.

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This large study shows that children with a proximal 16p11.2 deletion often have a predictable mix of learning differences, speech delays, autism or other mental‑health conditions, rapid early head growth, seizures, and a high risk of childhood obesity—which families can use to proactively plan early therapies, monitor growth and seizures, and coordinate care across development, behavior, and physical health rather than treating each issue in isolation.