Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias.

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This paper proposes that autism may begin very early in pregnancy if the brain’s “starter cells” divide or move at the wrong times, and for families with a 16p11.2 deletion or duplication, this idea helps explain how changes in this gene region could shift early brain wiring and later lead to learning, communication, or behavioral differences.