Chromosome 16p11.2 deletions: another piece in the genetic puzzle of childhood obesity.

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This article explains that some children with 16p11.2 deletions—especially those affecting the SH2B1 gene—have a biologically driven risk for early‑onset, severe obesity and insulin resistance, helping families understand that weight challenges are rooted in genetics and signaling pathways, and supporting the need for early medical, nutritional, and endocrine care rather than blaming diet or behavior alone.