Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes.

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This review article provides a comprehensive overview of the genetic causes and brain development mechanisms behind corpus callosum agenesis (when the brain's main connecting structure is missing or underdeveloped), which can occur in children with copy number variations like 16p11.2 deletions and duplications, helping families understand why this brain difference occurs and what research is being done toward potential therapies.