Combinations of genes at the 16p11.2 and 22q11.2 CNVs contribute to neurobehavioral traits.

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Researchers discovered that pairs of genes working together within the 16p11.2 region better explain the risk for autism, schizophrenia, obesity, and intellectual disability than single genes alone, suggesting that understanding how multiple genes interact may be key to unlocking why 16p11.2 changes affect behavior and development.