Complement contributes to hyperactive behavior in the 16p11.2 hemideletion mouse model

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Researchers discovered that an overactive immune pathway called the complement system (specifically a protein called C3) in the brain's striatum region may be causing hyperactive behavior in a mouse model of 16p11.2 deletion, and that blocking this pathway with medication reduced hyperactivity—suggesting a potential new treatment target for ADHD and related symptoms in children with 16p11.2 deletion.