Contextual modulation of sound processing in the auditory cortex.

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This review explains that the brain’s response to sounds changes depending on context—such as background noise, expectations, and attention—which helps families affected by 16p11.2 understand why a child may hear or react to the same sound very differently across situations and why supportive strategies like reducing background noise, providing predictable routines, and supporting emotional regulation can improve listening, communication, and comfort.