De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.

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This study found that spontaneous (de novo) genetic copy number changes, including at the 16p11.2 region, are significantly more common in people with schizophrenia and may contribute to the condition by disrupting brain cell communication pathways, which could be relevant for families whose 16p11.2 children show psychiatric or neurodevelopmental features.