Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders.

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This study shows that in 16p11.2 deletion syndrome, changes in a small group of genes can affect brain pathways involved in movement, motivation, and behavior—especially in boys—helping explain why symptoms like hyperactivity or reward‑seeking differences may look different based on sex and highlighting that these challenges arise from multiple genes working together rather than a single cause.