Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism.

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This study shows that in 16p11.2 genetic conditions, having a missing piece (deletion) or an extra copy (duplication) of the same chromosome region can lead to different brain and behavior differences—with deletions generally causing more significant challenges—helping families understand why symptoms vary so widely and why ongoing monitoring and individualized supports are important even within the same family.