Efficient Gene Expression in Human Stem Cell Derived-Cortical Organoids Using Adeno Associated Virus.
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This study shows that a virus-based tool (AAV) can efficiently deliver genes into lab-grown 3D mini-brains (organoids) made from human stem cells, offering researchers a faster and easier way to model brain conditions—a technique that could one day be applied to study 16p11.2-related brain development.