Focal cortical anomalies and language impairment in 16p11.2 deletion and duplication syndrome.

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This brain‑imaging study shows that both proximal 16p11.2 deletions and duplications are linked to small, specific differences in the brain’s language areas—especially on the left side—helping families understand that language challenges have a clear brain‑based cause and can be addressed by targeted, language‑focused therapies and evaluations rather than general supports alone.