Haplotype-specific MAPK3 expression in 16p11.2 deletion contributes to variable neurodevelopment.

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This study helps explain why children with a 16p11.2 deletion can be affected so differently by showing that small remaining genetic differences—especially in a key brain‑development gene called MAPK3—can change how brain cells grow and function, influencing whether a child has milder or more significant developmental challenges.