Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.

For: All,

This landmark study shows that 16p11.2 gene dosage affects body weight in opposite ways—deletions are strongly linked to obesity with increased hunger, while duplications are linked to being underweight and feeding difficulties—helping families and care teams understand that growth and eating challenges in 16p11.2 syndromes are biologically driven and should guide personalized nutritional, medical, and developmental supports rather than one‑size‑fits‑all advice.