Patient Brain Organoids Identify a Link between the 16p11.2 Copy Number Variant and the RBFOX1 Gene.

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Researchers used mini-brains (organoids) grown from patient stem cells to discover that the 16p11.2 deletion disrupts a gene called RBFOX1, which may help explain why some children with this deletion experience autism and other developmental differences—and could point toward shared treatments across related conditions.