Pharmacological Inhibition of ERK Signaling Rescues Pathophysiology and Behavioral Phenotype Associated with 16p11.2 Chromosomal Deletion in Mice.

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Researchers found that a drug blocking overactive ERK brain signaling during early development in mice with the 16p11.2 deletion improved brain structure and reduced autism-related behaviors like hyperactivity and memory problems, offering hope for future targeted treatments for families affected by this deletion.