The number of genomic copies at the 16p11.2 locus modulates language, verbal memory, and inhibition.

For: All,

This study shows that having fewer or extra copies of the proximal 16p11.2 region affects language, verbal memory, and self‑control in different ways, helping families understand why children with 16p11.2 deletions or duplications may have distinct strengths and challenges—and why evaluations and supports should be tailored to the specific CNV (deletion vs. duplication) rather than assuming the same learning or language profile for every child.